Stichting NoSelf Foundation proliferates the beneficial use of “cell-free nucleic acid based” technologies into the agriculture of the developing world., using a string of peer-reviewed NoSelf scientific publications that started in 2014. (Abstract below).

See us at BioControl & BioStimulant Congress Cairo, September 2026

Applications of non-self/self nucleic acids are microbiome modulation (humans-), gut flora stabilizers (livestock-) and biostimulants (crops). Some “biomimetic” uses of cell-free nucleic acids effects lead to novel antibiotics as well as to the suppression of weeds, nematodes, fungi, insects, bacteria with their own extracellular, randomly fragmented or secreted selfDNA. For farmers and growers we promote Diversity as a Service; restoring cell-free nucleic acid diversity within the monocultures of high- and mid-tech horticulture, neutralizing autotoxicity (and even reversing the negative self-DNA inhibition effects-) in such vulnerable cultures and reducing all kinds of growers’ troubles.

Diversity as a Service also enables farmers and growers to produce on-farm, for-farm and by-farm their biocontrol and biostimulant systems, improving their farm resilience. Especially in dry/hot areas.

Background IP: Patent 1 owned by No Self srl: The use of randomly fragmented genomic DNA. Patent 2 owned by No Self srl: The use of secreted DNA for specific inhibition. Patent 3 (pending-) owned by AND Biologicals BV: Use of nucleic acids as fertilizers and stimulants. Patent 4 owned by Koppert Biologicals BV: Mixing of dna molecules, uses thereof as biological inhibitor and method for production. Agricultural animation: 4 Minutes watching time, and worth it!

Commercial companies connected to us are AND Biotech AG, Basel, Switzerland, Algaementum, Portugal and AND Biologicals BV, Rotterdam, the Netherlands. We originated out of No Self SRL, Italy, a groundbreaking multi-disciplined, international, research and development organisation, led by Professor Dr. Stefano Mazzoleni, University of Napoli, Federico II.

Noself Foundation “democratizes” the crop input practices by demonstrating that evidence based, scientifically evaluated, natural solutions can help -especially- the developing world free itself from the burden of large and longterm R&D budgetary requirements with local solutions for local problems by local entities, quicker than usual. Want to know more? Get in touch with NoSelf Foundation and/or its subsidiary PuraNatura International BV. Chamber of Commerce, the Netherlands: 27303107 0000, address Arent Dirckszn Vosstraat 15, 2678CP De Lier, the Netherlands.

Upcoming speaker event:

BioControl & BioStimulant Congress Cairo, September 2026

Abstract

The research for new products against pathogens, parasites and infesting species, in both agriculture and medicine, implies huge and increasing scientific, industrial and economic efforts. Traditional approaches are based on random screening procedures searching for bioactive compounds. However, the success of such methodologies in most cases has been strongly limited by side-effects of the potential new drugs, especially toxicity and pharmacological resistance. The use of nucleic acids in drug development has been introduced searching for target-specific effect. In addition, a recent discovery revealed that randomly fragmented extracellular self-DNA may act as highly species-specific inhibitory product for different species, suggesting an unprecedented use of nucleic acids for biological control. On this base, a new scenario of pharmacological and biocontrol applications is discussed.