Diversity as a Drive
Divèrsity creates the conditions for resilient farms, living landscapes and self-supporting communities.

Not just bìodiversity!

NoSelf Foundation works on diversity as a living condition for resilience: In soils, crops, farms, food systems, communities, knowledge and local economies, even (or espècially- in boardrooms). Nothing- no system- thrives in splendid isolation; resilience emerges from relationships, exchange, feedback and diversity.

We advocate diversity as a practical source of resilience. We connect biological science, farmer knowledge, local production and systems thinking to help farms and farming communities become less dependent, more adaptive and better able to thrive under environmental and economic pressure. We proliferate the beneficial use of “cell-free nucleic acid based” technologies into the agriculture of the developing world, using a string of peer-reviewed NoSelf scientific publications that started in 2014. (Abstract below).

We focus on the Meditteranean Basin and presented at BioControl & BioStimulant Congress Cairo, September 2026, and spoke at the Morocco Tomato Conference Agadir, May 2026. We will be presenting at the NewAg Bangkok Conference April 27-29, 2027 to further our work in Asia.

Diversity as a Service
Practical knowledge-based biological services that enable growers to rebuild resilience by restoring functional biological diversity in crop-production systems.

Applications of the scientific findings may lead to the suppression of weeds, nematodes, fungi, insects, bacteria using their own extracellular, randomly fragmented or secreted selfDNA during the production and scale-up of applications. We support Diversity as a Service; restoring cell-free nucleic acid diversity, neutralizing autotoxicity (and even reversing the negative self-DNA inhibition effects-) in vulnerable cultures.

Diversity as a Service concepts enable farmers and -cooperatives to produce on-farm some biocontrol- and circular biostimulant systems to increase baseline biological resistance, improving their farm resilience, and improve the efficacy of current commercial applications. Especially in dry/hot areas. It seems that “Too much of “self” becomes toxic to the “self”, but lots of “non-self” are stimulating!

Noself Foundation believes evidence based, scientifically evaluated, natural solutions help farmers and growers with more local solutions for local problems by local entities. Want to know more? Get in touch with our CEO Peter Jens. Chamber of Commerce, the Netherlands: 27303107 0000, address Arent Dirckszn Vosstraat 15, 2678CP De Lier, the Netherlands.

We originated out of No Self SRL, Italy, a groundbreaking multi-disciplined, international, research organisation, led by Professor Dr. Stefano Mazzoleni, University of Napoli, Federico II.

Abstract

The research for new products against pathogens, parasites and infesting species, in both agriculture and medicine, implies huge and increasing scientific, industrial and economic efforts. Traditional approaches are based on random screening procedures searching for bioactive compounds. However, the success of such methodologies in most cases has been strongly limited by side-effects of the potential new drugs, especially toxicity and pharmacological resistance. The use of nucleic acids in drug development has been introduced searching for target-specific effect. In addition, a recent discovery revealed that randomly fragmented extracellular self-DNA may act as highly species-specific inhibitory product for different species, suggesting an unprecedented use of nucleic acids for biological control. On this base, a new scenario of pharmacological and biocontrol applications is discussed.

Background IP on cell-free nucleotides: Patent 1 owned by No Self srl: The use of randomly fragmented genomic DNA. Patent 2 owned by No Self srl: The use of secreted DNA for specific inhibition. Patent 3 (pending-) owned by AND Biologicals BV: Use of nucleic acids as fertilizers and stimulants. Patent 4 owned by Koppert Biologicals BV: Mixing of DNA molecules, uses thereof as biological inhibitor and method for production. Agricultural animation: 3 minutes watching time, and worth it.